Formation of corner waves in the wake of a partially submerged bluff body

We study theoretically and numerically the downstream flow near the corner of a bluff body partially submerged at a deadrise depth Δh into a uniform stream of velocity U, in the presence of gravity, g. When the Froude number, Fr=U/√gΔh, is large, a three-dimensional steady plunging wave, which is referred to as a corner wave, forms near the corner, developing downstream in a similar way to a two-dimensional plunging wave evolving in time. We have performed an asymptotic analysis of the flow near this corner to describe the wave's initial evolution and to clarify the physical mechanism that leads to its formation. Using the two-dimensions-plus-time approximation, the problem reduces to one similar to dam-break flow with a wet bed in front of the dam. The analysis shows that, at leading order, the problem admits a self-similar formulation when the size of the wave is small compared with the height difference Δh. The essential feature of the self-similar solution is the formation of a mushroom-shaped jet from which two smaller lateral jets stem. However, numerical simulations show that this self-similar solution is questionable from the physical point of view, as the two lateral jets plunge onto the free surface, leading to a self-intersecting flow. The physical mechanism leading to the formation of the mushroom-shaped structure is discussed

Considerations on bubble fragmentation models

n this paper we describe the restrictions that the probability density function (p.d.f.) of the size of particles resulting from the rupture of a drop or bubble must satisfy. Using conservation of volume, we show that when a particle of diameter, D0, breaks into exactly two fragments of sizes D and D2 = (D30−D3)1/3 respectively, the resulting p.d.f., f(D; D0), must satisfy a symmetry relation given by D22 f(D; D0) = D2 f(D2; D0), which does not depend on the nature of the underlying fragmentation process. In general, for an arbitrary number of resulting particles, m(D0), we determine that the daughter p.d.f. should satisfy the conservation of volume condition given by m(D0) ∫0D0 (D/D0)3 f(D; D0) dD = 1. A detailed analysis of some contemporary fragmentation models shows that they may not exhibit the required conservation of volume condition if they are not adequately formulated. Furthermore, we also analyse several models proposed in the literature for the breakup frequency of drops or bubbles based on different principles, g(ϵ, D0). Although, most of the models are formulated in terms of the particle size D0 and the dissipation rate of turbulent kinetic energy, ϵ, and apparently provide different results, we show here that they are nearly identical when expressed in dimensionless form in terms of the Weber number, g*(Wet) = g(ϵ, D0) D2/30 ϵ−1/3, with Wet ~ ρ ϵ2/3 D05/3/σ, where ρ is the density of the continuous phase and σ the surface tension

Three-dimensional stability of periodic arrays of counter-rotating vortices

International audienceWe study the temporally developing three-dimensional stability of a row of counter-rotating vortices defined by the exact solution of Euler's equations proposed by Mallier and Maslowe [Phys. Fluids 5, 1074 (1993)]. On the basis of the symmetries of the base state, the instability modes are classified into two types, symmetric and anti-symmetric. We show that the row is unstable to two-dimensional symmetric perturbations leading to the formation of a staggered array of counter-rotating vortices. For long wavelengths, the anti-symmetric mode is shown to exhibit a maximum amplification rate at small wave numbers whose wavelengths scale mainly with the period of the row. This mode could be interpreted as due to the Crow-type of instability extended to the case of a periodic array of vortices. For short wavelengths, symmetric and anti-symmetric instability modes are shown to have comparable growth rates, and the shorter the wavelength, the more complex the structure of the eigenmode. We show that this short wavelength dynamic is due to the elliptic instability of the base flow vortices, and is well modeled by the asymptotic theory of Tsai and Widnall. The effect of varying the Reynolds number was also found to agree with theoretical predictions based on the elliptic instability. © 2002 American Institute of Physics

Bubble size distribution resulting from the breakup of an air cavity injected into a turbulent water jet

We investigated experimentally the shape of the final size PDF(D) resulting from the breakup of an air bubble injected into the fully developed region of a high Reynolds number turbulent water jet. It is shown that the PDF(Dcirc) of the normalized bubble size Dcirc=D/D32, where D32 is the Sauter mean diameter of the distribution, has a universal single shape independent of the value of the turbulent kinetic energy of the water jet at the bubble injection point and of the air void fraction, α. The shape of the exponential tails characterizing each PDF(D) is shown to be only a function of the initial bubble size D0 and the critical bubble size Dc, defined as Dc=(1.46σ/ρ)3/5ɛ-2/5, where ɛ is the value of the dissipation rate of turbulent kinetic energy per unit mass at the air injection point

Prevalence of anxiety in medical students during the covid-19 pandemic: A rapid systematic review with meta-analysis

The novel coronavirus disease (COVID-19) pandemic has brought a great deal of pressure for medical students, who typically show elevated anxiety rates. Our aim is to investigate the prevalence of anxiety in medical students during this pandemic. This systematic review and mini meta-analysis has been conducted following the PRISMA guidelines. Two researchers independently searched PubMed on 26 August 2020 for cross-sectional studies on medical students during the COVID-19 outbreak, with no language restrictions applied. We then performed a manual search to detect other potentially eligible investigations. To the 1361 records retrieved in the initial search, 4 more were added by manual search on medRxiv. Finally, eight studies were finally included for qualitative and quantitative analysis, which yielded an estimated prevalence of anxiety of 28% (95% CI: 22–34%), with significant heterogeneity between studies. The prevalence of anxiety in medical students is similar to that prior to the pandemic but correlates with several specific COVID-related stressors. While some preventive and risk factors have been previously identified in a non-pandemic context, knowledge and cognitions on COVID-19 transmission, treatment, prognosis and prevention negatively correlate with anxiety, emerging as a key preventive factor that may provide a rationale for why the levels of anxiety have remained stable in medical students during the pandemic while increasing in their non-medical peers and the general population. Other reasons for the invariability of anxiety rates in this population are discussed. A major limitation of our review is that Chinese students comprised 89% the total sample, which could compromise the external validity of our work

Squalene through its post-squalene metabolites is a modulator of hepatic transcriptome in rabbits

Squalene is a natural bioactive triterpene and an important intermediate in the biosynthesis of sterols. To assess the effect of this compound on the hepatic transcriptome, RNA-sequencing was carried out in two groups of male New Zealand rabbits fed either a diet enriched with 1% sunflower oil or the same diet with 0.5% squalene for 4 weeks. Hepatic lipids, lipid droplet area, squalene, and sterols were also monitored. The Squalene administration downregulated 9 transcripts and upregulated 13 transcripts. The gene ontology of transcripts fitted into the following main categories: transporter of proteins and sterols, lipid metabolism, lipogenesis, anti-inflammatory and anti-cancer properties. When the results were confirmed by RT-qPCR, rabbits receiving squalene displayed significant hepatic expression changes of LOC100344884 (PNPLA3), GCK, TFCP2L1, ASCL1, ACSS2, OST4, FAM91A1, MYH6, LRRC39, LOC108176846, GLT1D1 and TREH. A squalene-enriched diet increased hepatic levels of squalene, lanosterol, dihydrolanosterol, lathosterol, zymostenol and desmosterol. Strong correlations were found among specific sterols and some squalene-changed transcripts. Incubation of the murine AML12 hepatic cell line in the presence of lanosterol, dihydrolanosterol, zymostenol and desmosterol reproduced the observed changes in the expressions of Acss2, Fam91a1 and Pnpla3. In conclusion, these findings indicate that the squalene and post-squalene metabolites play important roles in hepatic transcriptional changes required to protect the liver against malfunction. © 2022 by the authors. Licensee MDPI, Basel, Switzerland

Dietary squalene modifies plasma lipoproteins and hepatic cholesterol metabolism in rabbits

To evaluate the effects of squalene, the main unsaponifiable component of virgin olive oil, on lipid metabolism, two groups of male New Zealand rabbits were fed a 1% sunflower oil-enriched regular diet or the same diet containing 0.5% squalene for 4 weeks. Plasma triglycerides, total- and HDL-cholesterol and their lipoproteins were assayed. Analyses of hepatic lipid droplets, triglycerides, total- and non-esterified cholesterol, squalene, protein and gene expression, and cholesterol precursors were carried out. In the jejunum, the squalene content and mRNA and protein APOB expressions were measured. Finally, we studied the effect of cholesterol precursors in AML12 cells. Squalene administration significantly increased plasma total cholesterol, mainly carried as non-esterified cholesterol in IDL and large LDL, and corresponded to an increased number of APOB100-containing particles without accumulation of triglycerides and decreased reactive oxygen species. Despite no significant changes in the APOB content in the jejunum, the latter displayed increased APOB mRNA and squalene levels. Increases in the amounts of non-esterified cholesterol, squalene, lanosterol, dihydrolanosterol, lathosterol, cholestanol, zymostenol, desmosterol and caspase 1 were also observed in the liver. Incubation of AML12 cells in the presence of lanosterol increased caspase 1. In conclusion, squalene administration in rabbits increases the number of modified APOB-containing lipoproteins, and hepatic cholesterol biosynthesis is linked to caspase 1 probably through lanosterol. © The Royal Society of Chemistry

Prevalence of anxiety in the COVID-19 pandemic: An updated meta-analysis of community-based studies

Background: The unprecedented worldwide crisis caused by the rapid spread of COVID-19 and the restrictive public health measures enforced by some countries to slow down its transmission have severely threatened the physical and mental wellbeing of communities globally. Methods: We conducted a systematic review and meta-analysis to determine the prevalence of anxiety in the general population during the COVID-19 pandemic. Two researchers independently searched for cross-sectional community-based studies published between December 1, 2019 and August 23, 2020, using PubMed, WoS, Embase, and other sources (e.g., grey literature, manual search). Results: Of 3049 records retrieved, 43 studies were included. These studies yielded an estimated overall prevalence of anxiety of 25%, which varied significantly across the different tools used to measure anxiety. Consistently reported risk factors for the development of anxiety included initial or peak phase of the outbreak, female sex, younger age, marriage, social isolation, unemployment and student status, financial hardship, low educational level, insufficient knowledge of COVID-19, epidemiological or clinical risk of disease and some lifestyle and personality variables. Conclusions: As the overall global prevalence of anxiety disorders is estimated to be 7.3% normally, our results suggest that rates of anxiety in the general population could be more than 3 times higher during the COVID-19 pandemic. These findings suggest a substantial impact on mental health that should be targeted by individual and population-level strategies

SHALOS: Statistical Herschel-ATLAS lensed objects selection

Context. The statistical analysis of large sample of strong lensing events can be a powerful tool to extract astrophysical or cosmological valuable information. Their selection using submillimetre galaxies has been demonstrated to be very effective with more than ∼200 proposed candidates in the case of Herschel-ATLAS data and several tens in the case of the South Pole Telescope. However, the number of confirmed events is still relatively low, i.e. a few tens, mostly because of the lengthy observational validation process on individual events. Aims. In this work we propose a new methodology with a statistical selection approach to increase by a factor of ∼5 the number of such events within the Herschel-ATLAS data set. Although the methodology can be applied to address several selection problems, it has particular benefits in the case of the identification of strongly lensed galaxies: objectivity, minimal initial constrains in the main parameter space, and preservation of statistical properties. Methods. The proposed methodology is based on the Bhattacharyya distance as a measure of the similarity between probability distributions of properties of two different cross-matched galaxies. The particular implementation for the aim of this work is called SHALOS and it combines the information of four different properties of the pair of galaxies: angular separation, luminosity percentile, redshift, and the ratio of the optical to the submillimetre flux densities. Results. The SHALOS method provides a ranked list of strongly lensed galaxies. The number of candidates within ∼340 deg2 of the Herschel-ATLAS surveyed area for the final associated probability, Ptot > 0.7, is 447 and they have an estimated mean amplification factor of 3.12 for a halo with a typical cluster mass. Additional statistical properties of the SHALOS candidates, as the correlation function or the source number counts, are in agreement with previous results indicating the statistical lensing nature of the selected sampleJGN acknowledges financial from the Spanish MINECO for a “Ramon y Cajal” fellowship (RYC2013-13256). DH, FA, and LT acknowledge financial support from the I+D 2015 project AYA2015-64508-P (MINECO, FEDER)